Institut Necker Enfants Malades (Necker Institute for Sick Children) (INEM)

We are an international research Center in Molecular Medicine. We are affiliated at the Paris Descartes University, Inserm and CNRS. Our mission is to combine insights obtained through basic and clinical research and develop innovative therapeutic and diagnostic strategies focused on medical specialties represented in the Necker hospital. These include immune disorders, haematological diseases, infectious diseases, kidney diseases, cystic fibrosis and endocrinological disorders.

Our location on the Necker campus and the close interaction between the research labs and the clinical departments is one of our major strengths creating a highly dynamic environment and allowing “from bench to bedside” activities. The research proposal of the teams are highly consistent with this mission and most groups have very tight connections with clinical departments, mostly through clinicians with joint appointments in research labs and clinical departments.

For over 40 years, the development of renal transplants and bone marrow transplants, the phenotyping of autoimmune diseases and genetic diseases, allowed most of the major medical advances of today. The major asset of the Institute Necker-Enfants Malades comes from the plurality of skills, the freedom and creativity of its researchers, their desire to diversify their research topics. Translational activities will be pursued and promoted as much as possible. Indeed, this group of PIs has filed 24 patents, 4 of which are licenced to pharmaceutical companies. 13 R&D contracts have been signed with industry and 3 start-up companies incorporated with one of the above PIs as founder.

To further strengthen the link with the socio-economic world, we intend to devote one floor of our research building to hosting private entities, either small companies or teams from bigger pharmaceutical industries wishing to collaborate with groups of the Necker-Enfants Malades Institute.

Our mission

Here is our mission: to diagnose faster; invent new therapeutic strategies to find new cures and treat patients and children with rare diseases; closely integrate research and clinicalservices focusing on the problems of patients and sick children; create a dynamic environment that fosters the transfer activities, source of innovation and medical progress. And here our research in the coming years:

Understanding the molecular mechanisms of leukemia is to use targeted therapies and avoid chemotherapy whose collateral damage is known

Defeating diabetes, especially the type 1 in children (440,000 in the world), is to address the treatment of autoimmune diseases, more and more frequent in developed countries, as the case for multiple sclerosis or lupus.

Succeed one day to control the immune system, thanks to the long experience and considerable clinical material at the Necker hospital on kidney and bone marrow transplantations, is a priority

Seek to determine the mechanisms responsible for bacterial meningitis, debilitating in a few hours a perfectly healthy child or subject, is essential to develop effective and safe vaccines.

Apply our knowledge of metabolism and growth to promote innovative and personalized therapies in the field of kidney disease, diabetes, cystic fibrosis, muscular dystrophy and various solid tumors.

Contact

Martine Roulet
Faculté de Médecine Paris Descartes
Bâtiment Leriche – Etage 4
14 Rue Maria Helena Vieira da Silva – CS61431
75993 Paris Cedex 14, France

Tél.: 0033 – (0)1 72 60 63 95

Web: http://www.institut-necker-enfants-malades.fr/